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M9480853.TXT
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1994-09-05
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Document 0853
DOCN M9480853
TI Plasma-levels of IL-2R and IL-6 in perinatally HIV-infected children.
DT 9410
AU Fendt D; Cruciani M; Fioredda F; Loy A; Concia E; Bassetti D; Institute
of Infectious Diseases, University of Verona, Italy.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-12). Unique
Identifier : AIDSLINE ASM94/94313092
AB OBJECTIVE: The relationship between plasma-levels of IL-2R and IL-6,
known prognostic markers of HIV-infection (CD4 count, p24 antigenemia)
and progression into symptomatic disease in children was investigated.
METHODS: 10 children (5 male, 5 female, aged 3-7 years) with perinatal
HIV-infection in different clinical stages were included in a
prospective study with follow-up over a one-year period. At study entry
2 pts. were classified in stage P1B, 3 in P2A, 2 in P2AF and 3 in AIDS.
Four children were p24-antigenemia negative and had CD4 count > 400/mm3
(> 20%) (Group I), while 6 pts. had positive p24 antigenemia and CD4
count < 400/mm3 (< 20%) (Group II). Every 3 months clinical/nutritional
status, CD4 count and p24 antigenemia were evaluated and plasma samples
were stored for determination of IL-2R and IL-6 levels by ELISA-testing.
RESULTS: Levels of IL-R ranged from 217-884 U/ml. There was significant
difference between IL-2R levels found in Group I (mean value 248 U/ml,
range 217-289 U/ml) and those found in Group II (mean value 360 U/ml,
range 235-884 U/ml) (p < 0.001). One child of Group II had disease
progression in AIDS during follow-up (CMV-chorioretinitis) preceded 4
months before diagnosis by 2-fold increase of IL-2R levels.
Plasma-levels of IL-6 ranged from 0-270 pg/ml. Positive determinations >
10 pg/ml were found significantly more frequently in patients in stage
P2AF and AIDS (p < 0.02) and exclusively in children with deficit of
weight for height (wasting score < 97) (p < 0.001). No clear
relationship between CD4-count, p24 antigenemia and plasma IL-6 levels
was found. CONCLUSION: Monitoring plasma-levels of IL-2R and IL-6 may
have prognostic value in perinatal HIV-infection. Further observations
would be needed to confirm these findings.
DE Acquired Immunodeficiency Syndrome/BLOOD/IMMUNOLOGY Biological
Markers/BLOOD Child Child, Preschool Enzyme-Linked Immunosorbent
Assay/METHODS Female Human HIV
Infections/*BLOOD/IMMUNOLOGY/TRANSMISSION Interleukin-6/*BLOOD Male
Monitoring, Physiologic Pregnancy Pregnancy Complications, Infectious
Receptors, Interleukin-2/*ANALYSIS MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).